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Harald König

Dr. Harald König

Scientific staff
Research area Innovation processes and impacts of technology
Room: 230.1
Phone: +49 721 608-23293
h koenigUsc8∂kit edu

Institut für Technikfolgenabschätzung und Systemanalyse (ITAS)
Postfach 3640
76021 Karlsruhe


Studies in Biology at the University of Karlsruhe, Diploma degree 1988. Ph.D. (Dr. rer. nat.) 1992, with a thesis on in-vivo interactions of transcription factors with DNA. Habilitation and venia legendi in Genetics at the University of Karlsruhe 1999.

Professional background

1992 - 1994 Postdoctoral fellow at the Centre for Molecular Biology Heidelberg (ZMBH)
1995 - 1999 Research associate at the Institute of Toxicology and Genetics, Karlsruhe Research Centre
1999 - 2010 Lecturer (“Privatdozent”) at the Faculty for Chemistry and Biological Sciences, University of Karlsruhe and Karlsruhe Institute of Technology
1999 - 2011 Independent research group leader at the Institute of Toxicology and Genetics, Karlsruhe Research Centre and Karlsruhe Institute of Technology

Current positions

Member of scientific staff (senior researcher) at ITAS since 2011

Fields of work

  • Technology assessement of biosciences
  • Risk-benefit analysis of synthetic biology
  • Governance of synthetic biology and of emerging technologies

Selected publications at ITAS

König, H.
The illusion of control in germline-engineering policy. Nature Biotechnology, 35(2017)6, S. 502-506, DOI:10.1038/nbt.3884

König, H.; Frank, D.; Heil, R.; Coenen, Chr.
Synthetic biology's multiple dimensions of benefits and risks: implications for governance and policies. In: Boldt, J. (Hrsg.): Synthetic Biology. Metaphors, Worldviews, Ethics, and Law. Wiesbaden: Springer VS 2016, S. 217-232
(Technikzukünfte, Wissenschaft und Gesellschaft)

König, H.; Dorado-Morales, P.; Porcar, M.
Responsibility and intellectual property in synthetic biology. A proposal for using responsible research and innovation as a basic framework for intellectual property decisions in synthetic biology. EMBO reports 16(2015)9, S. 1055-1059, publ. online

Frank, D.; Heil, R.; Coenen, Chr.; König, H.
Synthetic biology's self-fulfilling prophecy - dangers of confinement from within and outside. Biotechnology Journal 10(2015)2, S. 231-235, publ. online, DOI: 10.1002/biot.201400477
Abstract englisch/htm


Sauter, A.; Albrecht, S.; Doren, D. van; König, H.; Reiß, T.; Trojok, R.; unter Mitarbeit von Sebastian Elsbach
Synthetische Biologie - die nächste Stufe der Bio- und Gentechnologie. Berlin: Büro für Technikfolgen-Abschätzung beim Deutschen Bundestag (TAB) 2015
(TAB-Arbeitsbericht Nr. 164)
Titelbild/jpg Volltext/pdf

König, H.; Frank, D.; Heil, R.; Coenen, Chr.
Synthetic genomics and synthetic biology applications between hopes and concerns. Current Genomics 14(2013)1, S. 11-24, DOI: 10.2174/138920291131401000

Selected external publications

König, H., Ponta, H., Rahmsdorf, U., Buscher, M., Schonthal, A., Rahmsdorf, H. J., and Herrlich, P. (1989)
Autoregulation of fos: the dyad symmetry element as the major target of repression. EMBO J 8, 2559-2566.

König, H., Ponta, H., Rahmsdorf, H. J., and Herrlich, P. (1992)
Interference between pathway-specific transcription factors: glucocorticoids antagonize phorbol ester-induced AP-1 activity without altering AP-1 site occupation in vivo. EMBO J 11, 2241-2246.

König, H., Pfisterer, P., Corcoran, L. M., and Wirth, T. (1995)
Identification of CD36 as the first gene dependent on the B-cell differentiation factor Oct-2. Genes Dev 9, 1598-1607.

König, H., Moll, J., Ponta, H., and Herrlich, P. (1996)
Trans-acting factors regulate the expression of CD44 splice variants. EMBO J 15, 4030-4039.

König, H., Ponta, H., and Herrlich, P. (1998). Coupling of signal transduction to alternative pre-mRNA splicing by a composite splice regulator. EMBO J 17, 2904-2913.

Matter, N., Marx, M., Weg-Remers, S., Ponta, H., Herrlich, P., and König, H. (2000)
Heterogeneous ribonucleoprotein A1 is part of an exon-specific splice-silencing complex controlled by oncogenic signaling pathways. J Biol Chem 275, 35353-35360.

Weg-Remers, S., Ponta, H., Herrlich, P., and König, H. (2001)
Regulation of alternative pre-mRNA splicing by the ERK MAP-kinase pathway. EMBO J 20, 4194-4203.

Matter, N., Herrlich, P., and König, H. (2002)
Signal-dependent regulation of splicing via phosphorylation of Sam68. Nature 420, 691-695.

Matter, N., and König, H. (2005)
Targeted 'knockdown' of spliceosome function in mammalian cells. Nucleic Acids Res 33, e41.

König, H., Matter, N., Bader, R., Thiele, W., and Müller, F. (2007)
Splicing Segregation: The Minor Spliceosome Acts outside the Nucleus and Controls Cell Proliferation. Cell 131, 718-729.

Tisserant, A., and König H. (2008)
Signal-Regulated Pre-mRNA Occupancy by the General Splicing Factor U2AF. PLoS ONE 3: e1418.

König, H., and Müller F. (2008)
Minor splicing: Nuclear dogma still in question. Proc Natl Acad Sci U S A 105: E37.

List of publications at ITAS